RNA Details
Disease Name
chronic heart failure
Tissue
heart
RNA Symbol
miR-129-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
rattus norvegicus
Detection Methods
NA
Target
Smurf1
Pathway
NA
PubMed ID
Title
miR-129-5p restores cardiac function in rats with chronic heart failure by targeting the E3 ubiquitin ligase Smurf1 and promoting PTEN expression
Year
2022
Function
"MiR-129-5p targeted Smurf1 and repressed the ubiquitination of PTEN, and promoted PTEN expression, thus improving the cardiac function of chronic heart failure rats."